New Jobs:

- Sr Scientist (Kintai)

- Oligonuc Chemist (Exicure)

- Scientist I (Celgene)

- Scientist I (Amgen)

Latest Internships:

- Cayman Chemical

  (Bio-Organic Chemistry)

- Complete Genomics

  (Chemistry)



Benzyl Protection








Common Conditions (Protection):


BnBr

Benzyl protection is typically performed using benzyl bromide (BnBr) or benzyl chloride (BnCl) in the presence of a base.[1][2]






Common Conditions (Deprotection):


H2 + Pd/C

Catalytic hydrogenolysis it the most common method of benzyl deprotection. Typical solvents include (MeOH, EtOH, EtOAc, and THF).[1][2]






References:


1) Kocienski, P. J.; Protecting Groups, 3rd Edition

2) Wuts, P. G. M.; Greene, T. W.; Greene's Protective Groups in Organic Synthesis, 4th Edition