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Other Names:

Methyl alcohol

General Information:


CAS Number: 67-56-1

Molecular Weight: 32.04 g/mol

Appearance: Colorless liquid

Melting Point: -98 C

Boiling Point: 64.7 C

Density: 0.791 g/mL at 25 C

Methanol is a common solvent with a wide variety of uses in organic chemistry.

Common Uses:

Reagent in Fisher esterifications

Reagent in Pinner reactions

Solvent for reactions

Solvent for silica gel chromatography

Procedure excerpt:

…The crude product was purified by silica gel column chromatography (0-10% MeOH/DCM) to provide the product…

Solvent for triturations

Procedure excerpt:

…MeOH (5 mL) and H2O (6 mL) were added to form a slurry which was stirred at RT for 1 h. The resulting solid was filtered to provide the product…

Solvent for recrystallizations

Procedure excerpt:

…purified on silica gel (0-10% EtOAc/hexane) to give a white solid. The solid was recrystallized from MeOH to provide the product…


Methanol is considered highly toxic to humans. It is metabolized by the body to formic acid. As little as 10 mL methanol can cause permanent blindness, 30-100 mL causes death. Methanol is a highly flammable liquid.


1) Patent Reference: WO2012112946, page 43, (11.2 MB)

2) Patent Reference: WO2014149164, page 234, (23.7 MB)

3) Patent Reference: WO2011014535, page 40, (17.3 MB)

4) Patent Reference: WO2015051043, page 60, (9.7 MB)

5) Patent Reference: WO2012129344, page 132, (7.3 MB)

6) Patent Reference: WO2010045258, page 120, (12.0 MB)

7) Wikipedia: Methanol (link)

8) Methanol (link)