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Michael Addition

Common Conditions:

Aza-Michael Addition

Aza-Michael addition involves the 1,4-addition (conjugate addition) of a nitrogen nucleophile to a Michael acceptor.[1]

Oxa-Michael Addition

Oxa-Michael addition involves the 1,4-addition (conjugate addition) of an oxygen nucleophile to a Michael acceptor.

Reaction Map:

The reaction map is intended to provide insight into possible reactions one step before and after the title reaction. It also serves as an alternative way to navigate the website, and as a means of coming up with retrosynthetic ideas. Click on the reaction arrow to visit the page.

For Amine:    
For Alcohol:  

Related Books:


1) Smith, M. B.; March's Advanced Organic Chemistry, 7th Edition