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Acid to Acid Chloride








Common Conditions:


SOCl2

Thionyl chloride (SOCl2) is commonly used to convert carboxylic acids to acid chlorides. Conditions typically involve stirring the substrate in neat SOCl2 at reflux for several hours. Sometimes a solvent is used (ex. ACN).





(COCl)2

Oxalyl Chloride [(COCl)2] is also commonly used to convert carboxylic acids to acid chlorides. The process typically involves stirring the substrate in DCM at RT with (COCl)2 and a catalytic amount of DMF.






Reaction Map:


The reaction map is intended to provide insight into possible reactions one step before and after the title reaction. It also serves as an alternative way to navigate the website, and as a means of coming up with retrosynthetic ideas. Click on the reaction arrow to visit the page.